HENDERSONVILLE, Tenn. (WTVF) — A set of siblings in Sumner County fighting a rare kidney disease for years are in kidney failure pleading for kidney donors. Twenty-five-year-old Nick Wilson and his ...

kidney cross section The Committee voted “no on the question of whether the provided evidence demonstrated that bardoxolone is effective in slowing the progression of CKD in patients with Alport ...

In late February, the US Food and Drug Administration (FDA) declined to grant marketing approval to the novel agent bardoxolone methyl as a treatment for Alport syndrome, which means this rare genetic ...

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor ...

Alport syndrome is a rare, genetic form of CKD caused by mutations in the genes encoding type IV collagen, which is a major structural component of the glomerular basement membrane in the kidney.

WATERTOWN, Mass., June 21, 2023 (GLOBE NEWSWIRE) -- Eloxx Pharmaceuticals, Inc. (NASDAQ: ELOX), a leader in ribosomal RNA-targeted genetic therapies for rare diseases, today highlighted recent Alport ...

A multi-institutional research group has succeeded in developing an exon-skipping therapy using nucleic-acid therapeutics for Alport syndrome, an incurable kidney disease that can progress to renal ...

Please provide your email address to receive an email when new articles are posted on . In a unanimous vote, an advisory group recommended the FDA not approve the drug baraxodone ethyl to treat Alport ...

Tests using a preclinical model of Alport syndrome suggests that turning off a cell signalling protein may significantly prolong life by preventing kidney scarring. A treatment strategy using an ...

Alport syndrome (AS) is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure. Depending on the mutated gene and the pattern of inheritance, ...

Inherited renal disease is responsible for 50% of cases of kidney failure in children and 20% of cases in adults. 1 Alport syndrome affects one in 5,000–10,000 individuals and is the most common ...