Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

Building on their pioneering 2018 research into how some of the body's cells, such as neurons and cardiac tissue, communicate via ions that flow through cellular channels, chemists at the University ...

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

Large-conductance calcium-activated potassium (BK) channels are critical determinants of smooth muscle function by mediating rapid feedback between intracellular calcium levels and membrane potential.

LONDON, July 25, 2024 (GLOBE NEWSWIRE) -- Kaerus Bioscience Ltd. (www.kaerusbio.com), a clinical-stage biotechnology company focused on developing therapeutics for rare genetic syndromes of ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a “ball-and-chain” channel-plugging mechanism, according to investigators ...

Even though the pore of the BK channel appears always open to potassium ions (red dots), because the pore is hydrophobic, it creates a vapor barrier (red circle) shutting off the flow of ions...most ...