Regulatory Affairs Professionals Society

Experts outline considerations for pivotal trial designs for new CGTs

As cell and gene therapies (CGTs) continue to advance, they have unique developmental features that may require innovation in ...
Healio

Q&A: What clinical trials overlook when studying ultraprocessed foods

Randomized controlled trials may not properly capture ultraprocessed foods’ health effects due to their designs and ...
The University of Chicago Chronicle

Are randomized controlled trials harming nonprofits?

In the 1940s, medical researchers began using randomized controlled trials to assess the efficacy of health interventions. In RCTs, researchers create randomly assigned treatment and control groups, ...
ascopubs.org

Clinical trial challenges in LMIC.

Evaluation of eligibility criteria in randomized controlled trials for chronic lymphocytic leukemia over 15 years. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract ...
Nature

Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial

Plasmodium falciparum (Pf) malaria remains a pressing public health problem. The Pf life cycle includes (1) sporozoites, injected by infected mosquitoes during feeding and then invade hepatocytes and ...
The Lancet

Challenges in assessing statin-associated adverse events

Collaboration report an individual participant data meta-analysis of double-blind randomised controlled trials (RCTs) assessing whether adverse outcomes listed in statin product labels are causally ...
CU Independent

Research Methodologies: Best Practices Guide for Implementing Slu Pp 332

The implementation of innovative medical solutions, such as Slu Pp 332, requires precise research methodologies to ensure ...