Phys.org

Proteomics method identifies ligand-binding proteins and binding sites in complex systems

In a study published in Nature Methods, a research group developed a highly sensitive proteomics method called peptide-centric local stability assay (PELSA), which enables the simultaneous ...
Nature

Protein embeddings and deep learning predict binding residues for various ligand classes

Despite immense progress in quantitative high-throughput proteomics, experimentally verified binding residues remain unknown for most proteins 4. In fact, reliable data remain so sparse to even ...
EurekAlert!

New proteomics method enables sensitive identification of ligand-binding proteins and their binding sites in complex system

In a study published in Nature Methods, a research group led by Prof. YE Mingliang from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences (CAS), collaborating with Prof. LUO ...
Nature

KaScape: a sequencing-based method for global characterization of protein‒DNA binding affinity

It is difficult to exhaustively screen all possible DNA binding sequences for a given transcription factor (TF). Here, we developed the KaScape method, in which TFs bind to all possible DNA sequences ...