Scientists have developed a new imaging technique that uses a novel contrast mechanism in bioimaging to merge the strengths of two powerful microscopy methods, allowing researchers to see both the ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

To further characterize the catalytic activity of LaccID, we purified recombinant enzyme from yeast S. cerevisiae using a protease-cleavable His 8-tag (Supplementary Fig. 5a). We first performed a ...

BERKELEY, Calif. and REDWOOD CITY, Calif., June 11, 2026 /PRNewswire/ -- In a landmark achievement in biological imaging, researchers at Biohub and the University of California, Berkeley today ...

This protocol provides comprehensive guidance for researchers, including those with limited electron microscopy (EM) experience, on the effective use of genetically encoded, multichannel EMcapsulin ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Electron microscopy is a powerful technique that provides high-resolution images by focusing a beam of electrons to reveal fine structural details in biological and material specimens. 2 Because ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...

How do organic solar cells work on the inside? The answer lies in structures far too small to see—and difficult to access even with advanced techniques. So far, researchers have relied mainly on X-ray ...

(a) A scanning electron microscope (SEM) image of the nanoneedle probe used for the measurements. (b) Elasticity map of a 1 µm × 1 µm area on the nuclear surface, showing the change in elasticity ...

Biohub and UC Berkeley show that the laser phase plate, a revolutionary device with a laser 100 million times brighter than the Sun, dramatically improves images obtained through cryo-electron ...