When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. It’s just as important to be able to resolve that inflammation and ...
Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...
The regulation of type I interferon (IFN-1) signaling is crucial for fine-tuning the innate immune response to combat pathogens, fight cancer and prevent autoimmune diseases. Disrupted IFN-1 signaling ...
Airway epithelial cells are frontline sentinels that detect, restrict, and orchestrate immune responses to respiratory viruses. Beyond canonical interferon ...
Interferon signatures may be a candidate biomarker for early identification of response to lupus nephritis induction treatment. Persistent type I interferon-driven transcriptional activity in ...
Higher baseline expression of interferon (IFN)-driven genes was tied to a better response to methotrexate in patients with juvenile idiopathic arthritis (JIA). Gene enrichment in the IFN-alpha (type I ...
Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...
Keratin is the fibrous, waterproof protein that builds everything from our hair and nails to a rhino's horn. However, a tiny ...
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