Intermediate filaments (IFs) are critical parts of the structure of cells. They are essential for both normal tissue structure and function. Enabling cells to withstand the stretch and pressure on the ...

Living cells are constantly exposed to a wide variety of mechanical stresses: heart and lungs must withstand expansion and contraction; our skin must be resistant to tearing whilst retaining ...

Cancer cell vascular invasion is a crucial step in the malignant progression toward metastasis. Here we used a genome-wide RNA interference screen with E0771 mammary cancer cells to uncover drivers of ...

Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilized and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, ...

Your cells aren’t just tiny blobs—they have an internal skeleton that keeps them in shape, moves things around, and even helps them adapt to change. This cytoskeleton is a dynamic network of filaments ...