Isothermal titration calorimetry (ITC) is one of the most robust and convenient techniques to thermodynamically examine intermolecular interactions by detecting any reaction heat that takes place in ...

Isothermal titration calorimetry (ITC) provides a label-free and direct measure of the heat exchanged during molecular binding events, enabling a complete thermodynamic profile of noncovalent ...

Complexes, such as protein/protein, nucleic acids/nucleic acid, protein/nucleic acid, protein/ligand, nucleic acid/ligand, are often difficult to crystallize even on well-defined biological systems, ...

Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...

Epigenetics refers to the study of heritable changes that occur in gene expression. Such changes are induced by non-genetic mechanisms, without causing any change in the DNA sequence or gene structure ...

All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes. Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering ...

MicroCal has introduced the new iTC200 Isothermal Titration Calorimeter using which researchers can achieve gold standard binding affinities with only 200 µl of sample. The iTC200 determines all ...