Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently.

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

K. Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, T.J. Richmond, "Crystal structure of the nucleosome core particle at 2.8 Å resolution," Nature, 389:251-60, 1997 ...