High-dose therapy with melphalan can prolong survival among patients with multiple myeloma. We assessed whether the addition of thalidomide, which has activity against advanced and refractory myeloma, ...

Scientists have studied thalidomide's target protein, cereblon (CRBN), and its binding protein, AMP-activated protein kinase (AMPK), which plays an important role in maintaining intracellular energy ...

More than five decades on, the battle for justice over birth defects caused by the drug thalidomide continues in only one European country: Spain. Spanish victims of thalidomide are the only ones ...

The primary objectives were to assess the feasibility and toxicities of thalidomide maintenance therapy following autologous peripheral stem cell transplantation and to evaluate the CR rate. The ...

Thalidomide is a medication with several different effects, one of which is promoting sleep in the context of insomnia. In a new study, researchers from the University of Tsukuba have discovered that ...

Nearly 50 years ago, an increasing number of babies worldwide were born with deformities and missing limbs. The babies had fallen victim to the teratogenic effects of thalidomide, a drug commonly ...

Explore how the thalidomide tragedy and metformin delay shaped the modern FDA and European drug approval processes and the ...

More than 50 years after the drug thalidomide hit the market as a remedy for nausea in pregnant women, researchers may finally have pinned down how it causes severe birth defects. Their results show ...

BERLIN – 1946 — Gruenenthal, a German pharmaceutical, is founded in Stolberg. 1954 — Gruenenthal discovers and patents thalidomide. 1957 — Thalidomide is first sold as Contergan in Germany. It is ...

The German manufacturer of a notorious drug that caused thousands of babies to be born with shortened arms and legs, or no limbs at all, issued its first ever apology Friday - 50 years after pulling ...

Melbourne woman Lynette Rowe is one of around 10,000 people born with thalidomide-related disabilities. Julian Smith/AAP The drug thalidomide has a notorious past. It was used between 1957-62 as a ...

Treatment with thalidomide led to a reduction in bleeding among patients with recurrent bleeding due to small-intestinal angiodysplasia (SIA), a randomized trial showed. In 150 patients, 68.6% of ...