Advancements in sequencing technology have made extensive collections of mutations and genomic information available 1,2,3,4. These datasets include millions of novel mutations that cannot all be ...
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
Since the discovery of RNA splicing and its role in gene expression, researchers have sought a set of rules, an algorithm or a computational model that could predict the splice isoforms, and their ...
An international team led by Monash University researchers has uncovered the genetic code governing the way genetic mutations affect mRNA and result in disease. This breakthrough, detailed in a new ...
Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...
"Understanding how the loss of this LUC7 protein in some AMLs alters splicing could help in the design of therapies that exploit these splicing differences to treat AML," Burge says. "There are also ...
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