The Wnt signalling pathway governs key processes in embryonic development, tissue homeostasis and stem cell maintenance by regulating gene expression through β-catenin–dependent and ...

Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have increased year by year. HCC research has increasingly focused on ...

Wnt signalling is a highly conserved cellular communication cascade that regulates bone formation, remodelling and repair through the modulation of osteoblast and osteoclast activity. Activation of ...

Researchers have described a large set of previously unrecognized enzymatic domains—named the Lipocone superfamily—and outlined their evolutionary pathway from bacterial defense molecules to key ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins as promising therapeutic targets for ...