AI-driven framework enables precise prediction of RNA splicing and isoform usage

RNA is the means of translating the genetic code embedded in DNA into proteins, which serve as enzymes, transporters, ...
Nature

RNA-rewriting candidate moves into the clinic

A growing list of editing tools can be used to make small changes to the genetic code, tweaking key nucleotides to address the underlying causes of diseases. But bigger edits are often needed, and ...
Technology Networks

AI Model Predicts RNA Splicing Across Human Tissues and Diseases

A new AI-based system combines genomic sequences and RNA-binding protein profiles to model complex RNA splicing patterns ...
Phys.org

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...
Science Daily

Biologists discover a new type of control over RNA splicing

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular process ...
GEN

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...