Endosomal trafficking and protein sorting constitute fundamental processes that govern the intracellular localisation and recycling of membrane proteins in eukaryotic cells. Endosomes act as central ...

F.-U. Hartl, W. Neupert, "Protein sorting to mitochondria: evolutionary conservations of folding and assembly," Science, 247:930-38, 1990. Franz-Ulrich Hartl (University of Munich, Germany): "In this ...

Inside every cell, a cleanup operation runs around the clock. Proteins are constantly damaged by wear and tear. Some can be repaired, while others must be dismantled and recycled. When this system ...

This study revealed two independent retrograde pathways: a sorting nexin–mediated pathway (orange) and a core retromer–mediated pathway (blue). In yeast, sorting nexins and the core retromer form a ...

The secretory pathway in eukaryotic cells is crucial for maintaining cellular function and physiological activities, as it ensures the accurate transport of proteins to specific subcellular locations ...

Draupnir’s novel SORTAC platform expands reach of targeted protein degradation to extracellular proteins, demonstrating in vitro and in vivo efficacy against difficult-to-drug targetsStudy further ...

Viruses are masters at invading cells thanks to specialized proteins that coat their surfaces. When scientists design vaccines, they often create versions of these viral surface proteins to study how ...