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Video: The Replisome
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The replisome complex in action: During DNA replication, helicase unzips the parent strands while single stranded binding proteins stabilize each strand. Topoisomerase relieves tension by cutting and rejoining DNA downstream of the replication fork. The primase enzyme catalyzes an RNA primer so that DNA polymerase III (guided by a sliding clamp) can begin polymerizing the new DNA molecule from the template. On the leading strand, this happens continuously as helicase continues unzipping the pare
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